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Optic atrophy
Neuro-Ophthalmology
Key Points
- •Optic atrophy is a SIGN, not a diagnosis; glaucomatous optic atrophy is the most common form worldwide
- •Primary (sharp margins, visible lamina cribrosa) vs secondary (blurred margins, gliosis after disc edema) vs consecutive (waxy pallor, attenuated vessels from retinal disease) - classic exam classification
- •Band (bow-tie) atrophy is pathognomonic of chiasmal lesions - always MRI for pituitary adenoma
- •LHON: mitochondrial, young males, bilateral sequential painless loss; 11778 (most common, worst prognosis), 14484 (best spontaneous recovery 37–65%)
- •Pallor > cupping = non-glaucomatous cause; cupping > pallor = glaucoma - a critical fundoscopic distinction
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17 more sections are included with the Clinical plan.
- Definition
- Epidemiology
- Aetiology and causes
- Pathogenesis
- Classification
- Risk factors and associations