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Idiopathic orbital inflammation

Oculoplasty

Key Points

  • •IOI is a diagnosis of exclusion - must rule out thyroid eye disease, lymphoma, sarcoidosis, GPA, and IgG4-RD before labelling as 'idiopathic'
  • •Dramatic response to corticosteroids within 24–48 hours is characteristic and serves as a diagnostic aid
  • •Unlike thyroid eye disease, IOI involves the extraocular muscle tendon - a key imaging differentiator on CT/MRI
  • •Up to 25–50% of previously labelled IOI cases may actually represent IgG4-related orbital disease - always check serum IgG4
  • •Sclerosing IOI has the worst prognosis and may require orbital radiotherapy or immunosuppression

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  • Definition
  • Epidemiology
  • Aetiology and causes
  • Pathogenesis
  • Classification
  • Risk factors and associations

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