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Central serous chorioretinopathy

Retina & Vitreous

Key Points

  • •CSC causes serous macular detachment due to choroidal hyperpermeability and RPE leakage - most common in men aged 20–55; corticosteroids are the strongest modifiable risk factor
  • •FFA shows inkblot (most common) or smokestack pattern; ICGA reveals underlying choroidal hyperpermeability and is essential for PDT planning
  • •Acute CSC resolves spontaneously in ~80–90% within 3–4 months; chronic CSC (>6 months) requires treatment to prevent permanent photoreceptor loss
  • •Half-dose PDT is the gold standard for chronic CSC - PLACE trial: 67% vs 29% complete SRF resolution at 7–8 months
  • •Part of the pachychoroid spectrum: PPE → CSC → PNV → PCV - all share thick choroid with dilated Haller layer pachyvessels

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17 more sections are included with the Clinical plan.

  • Definition
  • Epidemiology
  • Aetiology and causes
  • Pathogenesis
  • Classification
  • Risk factors and associations

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