Free previewYou're reading the free part of this topic. The rest is included with Clinical.See what's included
Familial exudative vitreoretinopathy (FEVR)
Retina & Vitreous
Key Points
- •FEVR is a hereditary vitreoretinal disorder with bilateral peripheral avascular retina, neovascularisation, vitreoretinal traction, and retinal detachment - occurring in full-term infants
- •Caused by mutations in Wnt/Norrin pathway genes: FZD4 (most common, AD), LRP5, NDP (X-linked), TSPAN12
- •Looks identical to ROP but occurs without prematurity or oxygen exposure - family history and genetic testing are key differentiators
- •FFA is the most important investigation - reveals peripheral avascular retina; mandatory for family screening
- •Laser to avascular retina is first-line treatment for neovascularisation; vitrectomy/scleral buckle for retinal detachment; family screening is essential
Free preview ends here
Keep reading Familial exudative vitreoretinopathy (FEVR)
17 more sections are included with the Clinical plan.
- Definition
- Epidemiology
- Aetiology and causes
- Pathogenesis
- Classification
- Risk factors and associations