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Vitreous substitutes

Retina & Vitreous

Key Points

  • •Gas tamponade: SF₆ (20% (18–20%) non-expansile, ~2 weeks) and C₃F₈ (14% non-expansile, ~6–8 weeks) are the main intraocular gases; ABSOLUTE CONTRAINDICATION: air travel and N₂O anaesthesia
  • •Silicone oil: long-term tamponade (1000 or 5000 cSt); causes hypermetropic shift (+5 to +7 D); remove at 3–6 months; complications: emulsification, glaucoma, cataract, band keratopathy
  • •PFCL: heavy liquid (SG ~1.76–2.0) for intraoperative retinal flattening only - NEVER left as long-term tamponade (retinal toxicity)
  • •Heavy silicone oil (Densiron/Oxane HD): for inferior retinal pathology; remove within 3 months
  • •Choice depends on: break location (superior vs inferior), PVR severity, positioning compliance, phakic status, air travel plans, and need for prolonged tamponade

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