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Drug-induced uveitis
Uvea
Key Points
- •Drug-induced uveitis is a diagnosis of exclusion - the critical clue is the temporal relationship between drug initiation and uveitis onset
- •Rifabutin causes a classic bilateral hypopyon uveitis - risk increases dramatically with CYP3A4 inhibitors (clarithromycin, fluconazole)
- •Prostaglandin analogues can cause anterior uveitis and CME, especially in pseudophakic eyes or those with prior uveitis history
- •Checkpoint inhibitors (ipilimumab, nivolumab, pembrolizumab) are an increasingly common cause as immunotherapy use expands in oncology
- •The cornerstone of management is identification and cessation of the offending drug - not escalation of immunosuppression
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17 more sections are included with the Clinical plan.
- Definition
- Epidemiology
- Aetiology and causes
- Pathogenesis
- Classification
- Risk factors and associations