Free previewYou're reading the free part of this topic. The rest is included with Clinical.See what's included
Masquerade syndromes
Uvea
Key Points
- •Masquerade syndromes are non-inflammatory conditions mimicking uveitis - suspect when uveitis is unresponsive to corticosteroids or has atypical features
- •Primary intraocular lymphoma (PIOL) is the most common malignant masquerade in adults - chronic vitritis with sub-RPE deposits, temporary steroid response, and IL-10:IL-6 ratio >1 on vitreous biopsy
- •Retinoblastoma is the most common masquerade in children - NEVER biopsy (risk of extraocular seeding); leukocoria is the hallmark
- •PIOL progresses to PCNSL in 60–80% within 2 years - MRI brain and CSF cytology are mandatory staging investigations
- •Non-malignant masquerades include retained lens fragments, UGH syndrome, IOFB (siderosis), and Schwartz-Matsuo syndrome (RD with elevated IOP)
Free preview ends here
Keep reading Masquerade syndromes
17 more sections are included with the Clinical plan.
- Definition
- Epidemiology
- Aetiology and causes
- Pathogenesis
- Classification
- Risk factors and associations