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Sarcoid uveitis
Uvea
Key Points
- •Periphlebitis with candle-wax drippings (perivenous exudates) is the hallmark posterior segment finding of sarcoid uveitis
- •IWOS criteria define 7 intraocular signs suggestive of sarcoidosis - know them for exams (mutton-fat KPs, TM nodules, tent-shaped PAS, snowballs, periphlebitis, disc granuloma, bilaterality)
- •Serum ACE has only 60% sensitivity - a normal ACE does NOT exclude sarcoidosis; conjunctival biopsy yields non-caseating granulomata in ~30% even from normal-appearing tissue
- •Non-caseating granulomata (sarcoidosis) vs caseating granulomata (TB) is the key histopathological distinction
- •Methotrexate 15–25 mg/week is the first-line steroid-sparing agent for sarcoid uveitis with the most evidence base
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17 more sections are included with the Clinical plan.
- Definition
- Epidemiology
- Aetiology and causes
- Pathogenesis
- Classification
- Risk factors and associations